The Problem with Traditional Trial Monitoring
Clinical trials still rely heavily on in-office visits for data collection, patient assessment, and compliance monitoring. This creates real challenges for sponsors and CROs: higher patient dropout rates, slower enrollment timelines, inconsistent data quality, and escalating per-patient costs. For dermatology and ophthalmology studies, subjective visual assessments introduce variability that can cloud endpoints and complicate regulatory submissions.
Appiell was built to solve these problems, not by replacing the investigator, but by extending the reach of the clinical site into the patient’s daily life.
What Is Appiell?
Appiell is a highly scalable, HIPAA-compliant SaaS platform that follows the patient journey from pre-screening through study completion. It integrates seamlessly with existing site workflows to capture high-quality clinical data, including images, eDiaries, and video, while reducing the burden on both patients and sites.
Unlike single-sponsor platforms tied to specific product portfolios, Appiell is fully company-agnostic. Any sponsor, any CRO, any therapeutic area within our network can leverage the platform without licensing restrictions or vendor lock-in.
Following Patient Journey Thru a Virtual Platform
- Highly scalable, secure HIPAA Compliant SaaS/Cloud based platform
- Back-end Data Analytics leading to quality products and treatment plans catered to specific patient populations
Virtual Platform provides an intuitive process for seamless data capture and engagement
Eligibility Screening
Pre-screening tools to help expedite patient recruitment and enrollment
eDiary, Image Capture, Surveys
Advanced image capture technology to reduce need for expensive office-based photography and frequent follow-up office visits
Notifications / Reminders
Adverse event monitoring to allow for accurate and timely reporting of side effects and medical complications
Real-Time Data Capture
Real-time data collection and management with AI predictive modeling for exploring secondary endpoints
Compliance, Continuous Engagement & Tracking
Video capture e-diaries and patient compliance monitoring to ensure patients adhere to strict clinical study protocols
Platform Capabilities
Eligibility Screening
Accelerate enrollment with digital pre-screening tools that identify and qualify candidates before they ever visit the site. Reduce screen failure rates and get the right patients into your study faster.
eDiary & Image Capture
Replace subjective visual assessments with standardized, high-resolution image capture from the patient’s own device. Advanced imaging technology enables remote monitoring of treatment response, reducing the need for in-office visits while improving data consistency across sites.
Real-Time Data & Predictive Analytics
Access study data as it’s collected, not weeks later in a monitoring report. AI-powered predictive modeling helps sponsors explore secondary endpoints and identify trends early, enabling faster decision-making and more informed protocol adjustments.
Compliance & Retention Tracking
Video-capture eDiaries and automated reminders keep patients engaged and on protocol. Real-time compliance dashboards give sponsors and sites early visibility into adherence issues before they become retention problems.
Why Sponsors Choose Appiell
Patient Experience Research Tools
Results Tracking
and Visualization
Periodic “selfies” – visually track treatment progress over time. Seeing improvement is motivational and reinforces the value of treatment.
Immediate
Feedback Loop
Any concerns/Positive outcomes can be reported directly. Fast feedback mechanism increases satisfaction & retention rates.
Data Collection
For Personalized Care
Data collected from taking periodic selfies can be used to tailor future treatments to patient’s specific needs and preferences.
Social Proof and
Community Building
Patients sharing their experience serves as a valuable social tool, attracting new users while creating a community around the product.
AI Validated Predictive Model
A pilot study was conducted to evaluate the functionality and potential of the virtual platform in the treatment of patients with Glabellar Frown Lines (GFL) using Botox®
– 71 patients were monitored at 6 centers in US
– Between age group 22 – 66 years old
– 92% Females / 1-5 Fitzpatrick Skin Types
Study data was published in the Fall 2022 edition of the Aesthetic Surgery Journal
AI Platform Agreement
Physician to Physician Agreement
Individual Physician Self Agreement
Physician to AI Platform Agreement
Key Findings
AI platform was more sensitive and consistent in detecting rhytids/fine lines compared to the physicians
The high-res photos obtained via AI platform were on par with professional clinic photos for assessment purposes
Majority of physicians (>80%) and patients (>87%) preferred the convenience provided by AI platform (assessments, communication, remote monitoring)
Appiell’s AI platform has the potential to significantly improve diagnoses through real time objective self assessments
“The future of clinical trials isn’t about replacing the investigator – it’s about extending their reach.”
Richard Panico – CEO Precefi
Built for Visual Specialties
Dermatology trials depend on visual assessment more than any other therapeutic area. Appiell was designed with this in mind. The platform’s image capture capabilities are optimized for skin conditions, wound healing progression and other visual endpoints where standardization and resolution directly impact data quality.
When combined with Precefi’s biomarker and translational services, Appiell enables a level of integrated data collection that traditional CRO models simply cannot match, objective imaging alongside molecular-level insights, all flowing through a single platform.
Appiell also enables a greater frequency of image capture than traditional site visits allow, giving sponsors a richer visual narrative of treatment response. This expanded photographic timeline becomes a powerful asset that sponsors can leverage when presenting clinical progress to prospective partners and investors.
How It Works
We customize the platform to your protocol, visit schedules, image capture requirements, eDiary prompts, and compliance parameters.
Sites and patients are onboarded with minimal training. The app is intuitive by design, built for patients, not IT departments.
Patients submit images, eDiary entries, and video check-ins on schedule. Data flows directly to the sponsor dashboard in real time.
AI-powered analytics surface trends, flag compliance issues, and support secondary endpoint exploration, all while the study is still running.
See the Platform
in Action
Schedule a demo to see how Appiell can integrate into your next study, or contact us to discuss how the platform fits your specific protocol requirements.
